Pigment Epithelium-derived Factor (PEDF) Prevents Retinal Cell Death via Pigment Epithelium- derived Factor-R (PEDF-R): Identification of a Functional Ligand Binding Site*
نویسندگان
چکیده
Background: PEDF has neurotrophic activity and interacts with PEDF-R, a membrane-linked lipase. Results: A PEDF-binding region of PEDF-R is required for PEDF-R enzymatic stimulation and peptides derived from this region block PEDF/PEDF-R-mediated retinal survival activities. Conclusions: A ligand binding domain is identified in PEDF-R, a critical receptor for PEDF’s survival activity. Significance: The findings provide mechanistic insight into the survival activity of PEDF.
منابع مشابه
Neural Stem Cell-based Intraocular Administration of Pigment Epithelium-derived Factor Promotes Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Crush Injury in Rat: An Experimental Study
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